Oxidative/anti-oxidative effects of colloidal silver ions and chlorhexidine in saliva and gingival fluid of periodontal patients

Background/Aim. Chronic periodontitis is an inflammatory disease. Oxidative stress important factor in progress, hence examining the antioxidative properties of antiseptics, such as chlorhexidine (CHX) and silver ions solution (SSI), a beneficial biomarker estimating recovery tissue impairment during periodontal disease treatment. Methods. This clinical trial was conducted on control group referred to healthy volunteers individuals with disease, divided into two subgroups: before after applying antiseptic treatments (CHX or SSI). Measurements oxidative/antioxidative parameters were addressed determine thiobarbituric acid products (TBARS) concentration total superoxide dismutase (tSOD) activity saliva gingival crevicular fluid (GCF) patients. Results. TBARS increased CHX treatment compared treatment, well both SSI CGF, controls groups Patients had tSOD treated SSI, patients Additionally, GCF (CHX, SSI) appropriate Conclusion. Our results revealed elevated lipid peroxidation which reflected promotion oxidative inflammation. The study suggests that antiseptics antioxidant may reduce damage initiated by Moreover, determination can be for diagnosing, monitoring, prognosis state